If you're ready to see your impact and unlock incredible career growth opportunities, join us, and build real world value.

THE WORK:

Ripple is the world's only enterprise blockchain solution for global payments. Today the world sends more than $155 trillion across borders. Yet, the underlying infrastructure is dated and flawed. Ripple connects banks, payment providers, corporates and digital asset exchanges via RippleNet to provide one streamlined experience to send money globally.

Ripple is growing rapidly, and we are looking for a hands-on Staff Software Engineering to help build the next generation of custody solutions that enable banks to instantly settle. Ripple's distributed financial technology outperforms today's banking infrastructure by minimizing costs, increasing processing speeds, and delivering end-to-end insight into fees, timing, and delivery.

WHAT YOU'LL DO:

• Build enterprise, distributed blockchain adjacent services to power Tokenization solutions for our customers
• Deliver reliable, high-throughput, low-latency applications supporting complex systems of financial asset management
• Provide technical direction for the project and team
• Participate in design reviews and help break complex projects into secure and maintainable systems
• Work with teams and leadership across the organization, including product, legal, and business development to think beyond the technical implications of your design decisions
• Continuously raise our standard of engineering excellence by implementing and driving best practices for coding, testing, and deployment
• Mentor other team members

WHAT YOU'LL BRING:

• 8+ years of hands-on software development experience on large scale distributed backend systems, with the last 4+ years in Java (with spring framework), and 1+ years experience working as a tech lead and mentoring other engineers
• Strong system design skills and experience
• A keen focus on performance, testing, and security
• Experience in building transactional systems (preferably in Payments / Banking / E-Commerce, Exchanges, Payment service, API service experience domains)
• Experience building cloud applications on AWS or GCP, and technologies such as Docker, Kubernetes.
• Experience with Agile development of distributed services, with a focus on robust software design, scalability, availability and security
• You are comfortable handling large, ambiguous problems and working with cross functional teams to craft solutions
• Eagerness to work openly and collaboratively with a diverse team
• Ability to encourage and drive engineering standard processes
• A positive attitude and a passion for sharing knowledge
• BS in Computer Science or similar

Pluses:

• Experience in stablecoin, exchanges, payment service, APIs experience.
• Interest in the cryptocurrency, decentralized finance(Defi) space.
• Understanding of exchange, crypto payment, decentralized finance, NFTs, etc.
• Experience with React or other javascript frameworks
• Experience with Solidity or Rust

WHO WE ARE:

Do Your Best Work

• The opportunity to build in a fast-paced start-up environment with experienced industry leaders
• A learning environment where you can dive deep into the latest technologies and make an impact. A professional development budget to support other modes of learning.
• Thrive in an environment where no matter what race, ethnicity, gender, origin, or culture they identify with, every employee is a respected, valued, and empowered part of the team.
• In-office collaboration for moments that matter is important to our culture, and we give managers and teams the flexibility to decide which 10+ days a month they come in.
• Weekly all-company meeting – business updates and ask me anything style discussion with our Leadership Team
• We come together for moments that matter which include team offsites, team bonding activities, happy hours and more!

Take Control of Your Finances

• Competitive salary, bonuses, and equity
• Competitive benefits that cover physical and mental healthcare, retirement, family forming, and family support
• Employee giving match
• Mobile phone stipend

Take Care of Yourself

• R&R days so you can rest and recharge
• Generous wellness reimbursement and weekly onsite & virtual programming
• Generous vacation policy – work with your manager to take time off when you need it
• Industry-leading parental leave policies. Family planning benefits.
• Catered lunches, fully-stocked kitchens with premium snacks/beverages, and plenty of fun events

Benefits listed above are for full-time employees.

Ripple is an Equal Opportunity Employer. We're committed to building a diverse and inclusive team. We do not discriminate against qualified employees or applicants because of race, color, religion, gender identity, sex, sexual identity, pregnancy, national origin, ancestry, citizenship, age, marital status, physical disability, mental disability, medical condition, military status, or any other characteristic protected by local law or ordinance.

Please find our UK/EU Applicant Privacy Notice and our California Applicant Privacy Notice for reference.

The post Staff Software Engineer, Stablecoin appeared first on Datafloq.

If you're ready to see your impact and unlock incredible career growth opportunities, join us, and build real world value.

THE WORK:

Ripple is the world's only enterprise blockchain solution for global payments. Today the world sends more than $155 trillion across borders. Yet, the underlying infrastructure is dated and flawed. Ripple connects banks, payment providers, corporates and digital asset exchanges via RippleNet to provide one streamlined experience to send money globally.

Ripple is growing rapidly, and we are looking for a hands-on Staff Software Engineering to help build the next generation of custody solutions that enable banks to instantly settle. Ripple's distributed financial technology outperforms today's banking infrastructure by minimizing costs, increasing processing speeds, and delivering end-to-end insight into fees, timing, and delivery.

WHAT YOU'LL DO:

• Build enterprise, distributed blockchain adjacent services to power Tokenization solutions for our customers
• Deliver reliable, high-throughput, low-latency applications supporting complex systems of financial asset management
• Provide technical direction for the project and team
• Participate in design reviews and help break complex projects into secure and maintainable systems
• Work with teams and leadership across the organization, including product, legal, and business development to think beyond the technical implications of your design decisions
• Continuously raise our standard of engineering excellence by implementing and driving best practices for coding, testing, and deployment

WHAT YOU'LL BRING:

• 5+ years of hands-on software development experience on large scale distributed backend systems, with the last 3+ years in Java (with spring framework)
• Strong system design skills and experience
• A keen focus on performance, testing, and security
• Experience in building transactional systems (preferably in Payments / Banking / E-Commerce, Exchanges, Payment service, API service experience domains)
• Experience building cloud applications on AWS or GCP, and technologies such as Docker, Kubernetes.
• Experience with Agile development of distributed services, with a focus on robust software design, scalability, availability and security
• You are comfortable handling large, ambiguous problems and working with cross functional teams to craft solutions
• Eagerness to work openly and collaboratively with a diverse team
• Ability to encourage and drive engineering standard processes
• A positive attitude and a passion for sharing knowledge
• BS in Computer Science or similar

Pluses:

• Experience in stablecoin, exchanges, payment service, APIs experience.
• Interest in the cryptocurrency, decentralized finance(Defi) space.
• Understanding of exchange, crypto payment, decentralized finance, NFTs, etc.
• Experience with React or other javascript frameworks
• Experience with Solidity or Rust

WHO WE ARE:

Do Your Best Work

• The opportunity to build in a fast-paced start-up environment with experienced industry leaders
• A learning environment where you can dive deep into the latest technologies and make an impact. A professional development budget to support other modes of learning.
• Thrive in an environment where no matter what race, ethnicity, gender, origin, or culture they identify with, every employee is a respected, valued, and empowered part of the team.
• In-office collaboration for moments that matter is important to our culture, and we give managers and teams the flexibility to decide which 10+ days a month they come in.
• Weekly all-company meeting – business updates and ask me anything style discussion with our Leadership Team
• We come together for moments that matter which include team offsites, team bonding activities, happy hours and more!

Take Control of Your Finances

• Competitive salary, bonuses, and equity
• Competitive benefits that cover physical and mental healthcare, retirement, family forming, and family support
• Employee giving match
• Mobile phone stipend

Take Care of Yourself

• R&R days so you can rest and recharge
• Generous wellness reimbursement and weekly onsite & virtual programming
• Generous vacation policy – work with your manager to take time off when you need it
• Industry-leading parental leave policies. Family planning benefits.
• Catered lunches, fully-stocked kitchens with premium snacks/beverages, and plenty of fun events

Benefits listed above are for full-time employees.

Ripple is an Equal Opportunity Employer. We're committed to building a diverse and inclusive team. We do not discriminate against qualified employees or applicants because of race, color, religion, gender identity, sex, sexual identity, pregnancy, national origin, ancestry, citizenship, age, marital status, physical disability, mental disability, medical condition, military status, or any other characteristic protected by local law or ordinance.

Please find our UK/EU Applicant Privacy Notice and our California Applicant Privacy Notice for reference.

The post Senior Software Engineer, Stablecoin appeared first on Datafloq.

If you're ready to see your impact and unlock incredible career growth opportunities, join us, and build real world value.

THE WORK:

We are looking for Software Engineers who are passionate about solving high-reaching problems in the cross-border payments space. We are passionate about our engineers' growth and place a premium on career development. You will have a high degree of accountability and responsibility from Day 1.

WHAT YOU'LL DO:

• Be an ambitious builder, working up and down the stack, mixing software engineering, data engineering, and distributed systems knowledge to build modern enterprise payment applications.
• Build reliable, high-throughput, low-latency microservices to power flawless cross-border transactions.
• Participate in the full software development lifecycle by capturing requirements, leveraging sound software design principles, and ensuring operational excellence with unit and integration testing
• Work with teams across the organization, including product, legal, and business development to think beyond the technical implications of your design decisions
• Continuously raise our standard of engineering excellence by implementing and driving best practices for coding, testing, and deployment
• Proactively identify customer and infrastructure problems and drive corresponding solutions.
• Mentor and support the growth of junior engineers.

WHAT YOU'LL BRING:

• 6+ years of hands-on Software Development experience on large-scale distributed systems, with the last 4-6+ years in Java or similar (Golang, Scala, etc).
• Experience in building transactional systems backed by modern persistence technologies (Aurora, DynamoDB, etc.)
• Experience with Agile development of distributed services, with a focus on robust software design, scalability, and security.
• Experience building and deploying containerized applications into modern distributed computing environments (Kubernetes, Nomad, etc.)
• Eagerness to work openly and collaboratively with a diverse team
• Ability to encourage and drive engineering best practices
• A positive demeanour and a passion for sharing knowledge
• BS or equivalent experience in Computer Science or similar

Other common names for this role:

WHO WE ARE:

Do Your Best Work

• The opportunity to build in a fast-paced start-up environment with experienced industry leaders
• A learning environment where you can dive deep into the latest technologies and make an impact. A professional development budget to support other modes of learning.
• Thrive in an environment where no matter what race, ethnicity, gender, origin, or culture they identify with, every employee is a respected, valued, and empowered part of the team.
• In-office collaboration for moments that matter is important to our culture, and we give managers and teams the flexibility to decide which 10+ days a month they come in.
• Weekly all-company meeting – business updates and ask me anything style discussion with our Leadership Team
• We come together for moments that matter which include team offsites, team bonding activities, happy hours and more!

Take Control of Your Finances

• Competitive salary, bonuses, and equity
• Competitive benefits that cover physical and mental healthcare, retirement, family forming, and family support
• Employee giving match
• Mobile phone stipend

Take Care of Yourself

• R&R days so you can rest and recharge
• Generous wellness reimbursement and weekly onsite & virtual programming
• Generous vacation policy – work with your manager to take time off when you need it
• Industry-leading parental leave policies. Family planning benefits.
• Catered lunches, fully-stocked kitchens with premium snacks/beverages, and plenty of fun events

Benefits listed above are for full-time employees.

Ripple is an Equal Opportunity Employer. We're committed to building a diverse and inclusive team. We do not discriminate against qualified employees or applicants because of race, color, religion, gender identity, sex, sexual identity, pregnancy, national origin, ancestry, citizenship, age, marital status, physical disability, mental disability, medical condition, military status, or any other characteristic protected by local law or ordinance.

Please find our UK/EU Applicant Privacy Notice and our California Applicant Privacy Notice for reference.

The post Senior Software Engineer appeared first on Datafloq.

As a Clinical Data Manager you will provide support and technical expertise in the management and processing of clinical data, within assigned projects to ensure that they are executed in efficiently, accurately to set timelines.

We can consider a range of experience for this role as our client offers some training and support. You will need to work in their offices 3 days/ week in London.

Key Responsibilities:

• Report clinical trial progress and outstanding issues.
• Staff training for all projects to which assigned; both direct involvement in training and supervision of staff assigned to training.
• To ensure that all data management operations are conducted to SOPs; contribute to the ongoing revision/improvement of these SOPs.
• Creation of project specific documentation for assigned trials, i.e. the Data Management Plan and the Data Management File.
• Prepare database and edit check specifications.
• Creation and validation of Manual and SAS checks.
• Reconciliation of data from external sources (e.g. Serious Adverse Events, IVRS, Central Laboratory).
• To perform verification and User Acceptance Testing of configured databases.
• Data cleaning activities.
• To review SAS listings/SAS tables.
• To create CRF and eCRF completion guidelines, EDC system manuals and access instructions.
• Production of information/reports directly from the clinical database or via the appropriate procedure to request a new report from the appropriate department or vendor.
• To liaise with personnel at the sponsor company, or their designates, with Central Event Adjudication Committees (CEC) within clearly defined guidelines as determined by the Data Manager for matters concerning processing of data.
• Performance of QC checks (including spot checks) and Database Quality Assessments on the clinical databases of assigned projects.
• Perform other duties as assigned. The duties and responsibilities listed above are representative of the nature and level of work assigned and are not necessarily all-inclusive

OTHER SKILLS AND ABILITIES:

• The job holder must be computer literate and numerate with a willingness to adapt to various computer systems.
• It is essential that the job holder works with close attention to detail and is questioning about the validity of the data being entered and has an ability to phrase data queries in an understandable and impartial manner.
• To have the ability to train new staff and to monitor their performance

REQUIREMENTS:

• Life Science Degree, Nursing qualification, or relevant industry experience.
• All candidates will need to have current and valid eligibility to work in the UK in order to be considered for this role.

#clinicaldatamanager #scdm24 #acdm24 #clinicaltrials

The post Clinical Data Manager appeared first on Datafloq.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

We strive to create a diverse and inclusive workplace, while seeking talented individuals to work with us across the many functions that will allow us to deliver new medicines to transform the lives of patients. You will work with outstanding people who together pioneer the research, development and commercialization of bi-specific TCR therapies. We aim to create an environment where individual contributions and initiatives can be maximized, while fostering a culture of collaboration, based on respect and integrity. We want each individual employee to own their career, as part of high-performing teams, and in the context of on-the-job and formal continuous development and training, as well as constructive feedback. We always strive to identify ways to improve what we do and how we do it, by asking questions, voicing opinions, exploring various approaches and staying connected with healthcare professionals, patients, academia and other key partners.

The Principal Scientist In Silico Biologics Design will provide world class expertise in machine learning to drive the establishment of robust in silico methodologies that integrates computational predictions with empirical laboratory data to revolutionise the design of our class-leading T-cell receptor (TCR) drugs. Using our wealth of structural data, combined with further in-house and public domain data sets, the successful applicant will develop ML algorithms to impact the design of future drugs. This is an exciting technology-focussed role so innovation, execution and collaboration are key factors for success. Working closely with the In Silico and automation teams within Protein Engineering, you will provide scientific and technical leadership relating to machine learning that will ultimately result in further progression of our growing pipeline of first-in-class drugs to benefit patients. With our successful launch in 2022, of the world's first TCR based medicine, KIMMTRAK, which is also the first launched treatment for any solid tumour, you will be joining us at the most exciting time in our history, and be part of a team that values innovation, trust and collaboration.

KEY RESPONSIBILITIES

* To develop and assess advanced machine learning (ML) models for novel antibody and TCR drug candidate optimisation and, looking to impact de novo drug design in the future
* Utilise our extensive in-house structural and specificity data sets to extract further value
* Work with colleagues across Research to identify training data from the public domain and help shape the development of our in-house data sets to support the optimisation of ML algorithms
* Drive the establishment of virtual screening tools including:
o Protein structure prediction
o Affinity prediction
o Peptide human leukocyte antigen (pHLA) specificity prediction
o Developability prediction
* Assist with TCR library design for multifactorial lead optimisation
* Work with interdisciplinary teams across structural biology, next-generation sequencing (NGS), and bioinformatics and data science to integrate machine learning into TCR discovery and optimisation.
* Work with scientists to validate and integrate new methodologies into existing architecture.
* Promote utilisation of ML algorithms among colleagues and mentor and train others in their deployment
* Present research outcomes at all levels, including Protein Engineering lab meetings, Research leadership team meetings, other governance meetings and at external conferences

PERSON SPECIFICATION

Experience & knowledge

Essential

* Demonstrated ability to build and evaluate machine learning models
* At least 8 years of experience in antibody, TCR or biologics design, evidenced by a strong publication record.
* Proficiency with protein ML models such as AlphaFold, ESMFold, RFdiffusion, MPNN
* Advanced Python programming skills, focusing on data science and machine learning.
* Managed sizeable research projects, understanding the wider implications of project outcomes and strategic objectives.
* Demonstrates effective coaching skills and brings vision and strategy to life for others.
* Exceptional communication skills.
* Demonstrated ability to build and sustain networks and external collaboration with scientific leaders in the field.

Desirable

* Expertise in structural biology and modelling
* Experience in NGS analysis.
* Experience with biologics data management software including Genedata and in handling and integrating large-scale biological datasets from different sources.
* Familiarity with deploying and managing computational workflows on cloud platforms (e.g. AWS)

Education & qualifications

* PhD in Computational Biology, Computational Chemistry, Bioinformatics, or related discipline.

The post Principal Research Scientist – In Silico Biologics Design appeared first on Datafloq.

Our client takes pride in our open and collaborative company culture – it's at the heart of everything we do. Our aim is to support each other and set each other up for success.

Does this sound like you?:

Experience in data modelling, using statistical methods to identify behavioural and data patterns. Industry experience would be advantageous, but this is not clinical endpoint analysis so a different way of thinking about data and stats modelling is required.

An interest and/or experience in machine learning models would also be an advantage but not essential. This role will require you to write reproducible, robust code and so an understanding of the importance of good software development practices and interest in this area would be beneficial. Or if not, an appetite to learn!

Interpersonal Skills:

Self-motivated

Creative and visionary

Strong communication skills, ability to make a positive impact with internal and external stakeholders

Enjoy working in a small, but growing, results-oriented team

Ability to take responsibility for the consistency and quality of deliverables

Technical Skills (not exclusive)

Strong foundational knowledge of statistics (Hypothesis testing, point estimation, confidence intervals, numerical summaries, common distributions…)

Experience in statistical modelling and regression analysis

Programming skills in and statistical modelling skills in R and/or Python.

Understanding of package development would also be an advantage or with a willingness to learn.

Experience/interest in application of Machine Learning

Ability to review clinical protocols and understand the study design and subject visits schedules

Ability to demonstrate and apply critical thinking to KRI and data visualization design and centralized monitoring implementation

Ideally an understanding of clinical trial data and data structure

Desirable to have an understanding of software development practices (Agile, a collaboration tool such as Git, Testing/validation strategies, containerisation/similar)

As a highly valued team member, you can expect to be offered the right environment, compensation, and development opportunities to allow you to focus on being successful, and to support your colleagues to do the same.

In return, our client expects our team members to work hard, focusing on what really matters. We ask for honesty, thoughtful communication, and cross-functional support.

There isn't any sponsorship availabile at this company so you must have the right to work in the UK to be considered

Contact Gail Kniveton for more information

#RBQM #clinicaldatamanagement #datascience #datascientist

The post Data Scientist Clinical Trials appeared first on Datafloq.